周口市无偿献血者抗HCV阳性情况分析

Prevalence of anti-HCV among volunteer blood donors in Zhoukou

目的：了解周口市无偿献血者丙型肝炎病毒抗体（抗HCV）阳性情况。方法采用酶联免疫检测法，对周口市2007-2012年采集的200950份无偿献血者样本进行抗HCV双试剂检测，并对结果进行统计分析。结果2007-2012年无偿献血者抗HCV总阳性率为0．21％（416/200950），不同性别、年龄、学历献血者抗HCV阳性率比较，差异均有统计学意义（χ2分别为24．01、142．31、45．8，均P＜0．01），其中女性抗HCV阳性率（0．27％，205/75658）高于男性（0．17％，211/125292）；21～30岁组献血者阳性率（0．06％，38/63719）最低，＞40岁组阳性率（0．33％，162/48871）最高；学历越低，抗 HCV阳性率越高，初中学历人群阳性率为0．26％（107/41154）。2007-2012年，献血者抗HCV阳性率逐年下降（χ2＝14．576，P＜0．05）。结论该市无偿献血者中抗HCV阳性率较低，人群阳性率分布有差异。

Objective To investigate the prevalence of anti-HCV positive among volunteer blood donors in Zhoukou city. Methods A total of 200 950 blood specimens from voluntary blood donors in Zhoukou from 2007 to 2012 were detected for anti-HCV by double-antibody sandwich enzyme-linked immunosorbent assay, results were analyzed. Results The total positive rate of anti-HCV was 0. 21 %（416/200 950）, there were significant difference in positive rates of anti-HCV among populations of different genders, ages and educational background（X^2 = 24. 01, 142. 31,45. 8, respectively, all P〈0. 01）, the positive rate of anti-HCV in female was higher than that of male （[0. 27%,205/75 658] vs [0. 17%, 211/125 292]） ; the positive rate of anti-HCV was the lowest in donors aged 21 - 30 years （0. 06% ,38/63 719）, and highest in donors aged 〉40 years （0. 33%, 162/48 871 ） ; the lower donors received education, the higher positive rate of anti-HCV they had, the positive rate of anti-HCV in donors with junior high school education was 0. 26% （107/41 154）. The positive rate of anti HCV in blood donors decreased gradually from 2007 to 2012（X^2 = 14. 576,P〈0. 05）. Conclusion The positive rate of anti-HCV is low in voluntary blood do nors in Zhoukou and is significantly different among different populations.