喹硫平与利培酮对女性精神分裂症患者血清催乳素及体重指数的影响分析

Effect of quetiapine and risperdal on serum prolactin levels and body mass index of female patients with schizophrenic

目的 探讨喹硫平与利培酮对女性精神分裂症患者血清催乳素和体重指数BMI的影响.方法 选取未用药或停药1月的100例女性精神分裂症患者,随机分为喹硫平组和利培酮组治疗,分别给予喹硫平与利培酮单独治疗12周.在治疗前后分别测定血清催乳素水平和体重,计算体重指数BMI.结果 治疗12周后喹硫平组血清催乳素和体重指数BMI无明显增加,利培酮组则显著增加,体重指数BMI和催乳素水平变化呈正相关.结论 喹硫平对女性患者催乳素和体重BMI指数无明显影响,利培酮对女性患者催乳素和体重指数BMI影响明显.

Objective To investigate the influence of quetiapine and risperdal on the serum prolactin levels and body mass index （BMI） of female patients with schizophrenic.Methods 100 female schizophrenic patients,who had never used medication or had discontinued medication for a month,were randomly divided into two groups,the quetiapine group and the risperdal group.Each group was provided with quetiapine or risperdal,respectively,for 12 weeks.The serum prolactin level and body weight were recorded and BMI was calculated for each patient,before and after the treatment.Results After 12 weeks of treatment,the serum prolactin level and BMI in the quetiapine group had no significant increase,while they increased significantly in the risperidone group.It also showed that BMI and serum prolactin level changes had positive correlation.Conclusion Risperdal has significant effect on the serum prolactin and BMI of female schizophrenic patients,but quetiapine has not.