CD64指数测定在先天性心脏病术后并发严重感染中的诊断价值

Value of CD64 in diagnosis of infection for children with congenital heart disease after operation

目的探讨中性粒细胞CD64指数测定在先心病术后并发严重感染中的诊断价值。方法 2011年3月—2013年3月该院心肌外科收治的先心病患儿中术后并发全身炎症反应综合征(SIRS)的患儿30例,按其术后是否并发感染分为服毒症组(15例)和非感染组(15例)。进行外周血中性粒细胞CD64指数测定,并与C反应蛋白(CRP)进行比较。结果脓毒症组CD64指数明显高于非感染组,差异有统计学意义(t=3.312,P<0.01);脓毒症组CRP高于非感染组,但差异无统计学意义(P>0.05);ROC曲线分析显示CD64诊断感染的灵敏度为灵敏度为85.7%,特异度为92.3%。结论细菌感染时CD64指数明显增高,具有较高灵敏性和特异性,可以作为先心病患儿术后并发严重感染的早期诊断依据。

Abstract：Objective To explore the value of neutrophile CD64 molecules in diagnosis of severe infection for children with congenital heart disease after operation. Methods Thirty children with congenital heart disease accompanied by SIRS after operation who were admitted to Anhni Provincial Children＇s Hospital during Mar 2011 to Mar 2013 were assigned into sepsis group（ n = 15 ）and non-infection group （ n = 15 ）. CD64 was evaluated and compared with CRP. Results The level of CD64 was higher in sepsis group than that of non-infection group ,with significant difference（ t = 3. 312 ,P 〈0.01 ）. The level of CRP was higher in sepsis group than that of non-infection group, but with no significant difference （P 〉 0.05 ）. The sensitivity of CD64 was 85.7 %, and specificity was 92.3 % under the ROC curve. Conclusions The CD64 can be used as a sensitive diagnostic indicators for bacterial infection in children, and as an early diagnosis indicators for severe infection of children with congenital heart disease after operation.