老年男性高血压患者睾酮水平与颈动脉内膜-中层厚度的相关性研究

Correlation between testosterone levels and carotid artery intima-media thickness in aged male hypertensive patients

目的探讨老年男性高血压患者的血浆睾酮(T)水平与颈动脉内膜-中层厚度(IMT)的相关性。方法选取90例老年男性原发性高血压患者,根据有无颈动脉粥样硬化斑块,分为有斑块组(n=56)和无斑块组(n=34);另选取80例健康老年男性作为对照组。检测所有受试对象的血浆T水平、颈动脉IMT,分析指标间的相关性。结果有斑块组收缩压(SBP)、舒张压(DBP)、IMT水平均高于无斑块组和对照组(P<0.05或P<0.01),而血浆T水平均低于这2组(P<0.05或P<0.01);老年男性高血压患者血压、血浆T水平与颈动脉IMT之间均具有相关性,血浆T水平与SBP、DBP、IMT均呈负相关(P<0.01)。结论老年男性高血压患者的T水平与动脉粥样硬化程度呈负性相关,其血浆T水平可为疾病评估、激素替代治疗等提供理论参考依据。

Objective To investigate the association between plasma testosterone levels and carotid intima-media thickness（IMT） in the elderly hypertensive male patients. Methods Ninety cases of elderly male patients with primary hypertension were enrolled, and they were divided into plaque group （n= 56） and no plaque group （n= 34） according to the presence of carotid atherosclerotic plaques. And another 80 healthy elderly men were chosen as control group. The plasma level of testosterone （T） and carotid IMT of all the subjects were detected and the correlations between the parameters were analyzed. Results The levels of SBP, DBP, IMT was highest and the T level was lowest in plague group, followed by no plaque group, control group. There were significant correlation of blood pressure and plasma T levels with IMT, and negative correlation of T level with SBP, DBP and IMT in the elderly male patients with hypertension （P〈0. 01 ） Conclusions Plasma T level is significantly associated with the severity degree of atherosclerosis in the elderly male patients with hypertension, which might provide theoretical reference for hormone replacement therapy.