来曲唑与克罗米芬治疗多囊卵巢综合征患者效果对比分析

Contrastive analysis for the therapeutic effect of letrozole and clomiphene on polycystie ovarian syndrome

目的探讨来曲唑与克罗米芬治疗多囊卵巢综合征(PCOS)患者的疗效。方法收集PCOS患者72例,随机分为观对照组和观察组,每组36例,对照组给予克罗米芬治疗,治疗组给予来曲唑治疗,比较分析促排卵效果及生殖激素水平。结果观察组的子宫内膜厚度、排卵率和周期妊娠率均明显高于对照组(P<0.05);观察组的血清促卵泡素水平明显高于对照组(P<0.01),而观察组的雌二醇水平则低于对照组(P<0.05)。结论与传统药物克罗米芬相比,来曲唑具有较高的排卵率、周期妊娠率及子宫内膜厚度,增加血清促卵泡素水平,减少雌二醇水平,负作用较小。

Objective To observe the therapeutic effect of letrozole and clomiphene on polycystie ovarian syndrome （ PCOS） .Methods Seventy-two patients with PCOS were randomly divided into observation group and control group ,with 36 patients in each group .The patients in control group were treated by clomiphene ,however ,the patients in observation group were treated by letrozole .The ovulation induction effect and reproductive hormone levels were observed and compared between the two groups .Results The thickness of endometrium , ovulation rate and cycle pregnancy rate in observation group were significantly higher than those in control group （ P 〈0.05）.The serum levels of FSH in observation group were significantly higher than those of control group （ P 〈0.01）,however,estradiol levels in observation group were obviously lower than those in control group （ P 〈0.01）.Conclusion As compared with clomiphene,letrozole has higher ovulation rate,cycle pregnancy rate and thickness of endometrium ,which can increase FSH levels and reduce estradiol levels ,with less adverse effects .