CD105在结直肠癌组织中的表达及与血管生成的关系

Expression of CD105 in colorectal carcinoma and its relationship with angiogenesis

目的分析CD105在结直肠癌组织中的表达并探讨其与血管生成的关系。方法应用免疫组织化学方法检测60例原发性结直肠癌组织、20例结直肠腺瘤组织、10例结直肠黏膜组织中CD105的表达。结果 60例结直肠癌标本平均微血管计数为(30±8)条。结直肠癌CD105标记的MVD值明显高于结直肠腺瘤组织(P<0.01)。CD105标记的MVD值与肿瘤分期、淋巴结转、远处转移明显差异有统计学意义(P<0.01),而与患者的年龄、性别、肿瘤直径、大体类型、病理类型及组织学分级均差异无统计学意义(P>0.05)。结论 MVD在TNM分期、淋巴结转移情况和远处转移情况有明显差异,提示CD105表达密度增强的患者浸润转移率高、预后差。

Objective To investigate the expression of CD 105 in colorectal carcinoma and to explore the relationship between the expression and angiogenesis .Methods Immunohistochemistry was used to detect the expression of CD 105 in 60 cases of primary colorectal carcinomas ,20 cases of colorectal adenomas and 10 cases of normal colorectal tissues .Results The average microvessel number labeled with CD 105 in 60 cases of colorectal carcinoma was 30 ＆#177;8.The MVD value in primary colorectal carcinomas labeled with CD 105 was significantly higher than that in colorectal adenomas （ P 〈0.01）,which was closely related to TNM stage,lymph node metastasis and distant metastasis （ P 〈0.01）,however,which was not correlated with patient’s sex and age,the tumor’s size,histological type,pathological type and the degree of differentiation （ P 〉0.05）. Conclusion MVD has significant differences at the respects of TNM stage ,lymph node metastasis and distant metastasis, which suggests that the patients with enhancement of CD 105 expression density have higher rates of tumor metastasis and poorer prognosis .