卵巢癌患者手术治疗前后血清HMGB1、VEGF水平的变化及临床意义

The changes and clinical significance of serum levels of HMGB1,VEGF before and after operation in patients with ovarian carcinoma

目的研究卵巢癌患者手术治疗前后血清高迁移率族蛋白B1(high mobility group box-1,HMGB1)、血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的变化及临床意义。方法采用酶联免疫吸附法(ELISA)检测40例卵巢癌、60例卵巢良性肿瘤患者血清HMGB1、VEGF的表达水平,另设30例健康人作为对照组。结果卵巢癌组HMGB1、VEGF表达水平与卵巢良性肿瘤组及对照组比较显著增高(P<0.05),而卵巢良性肿瘤组和对照组比较,差异无统计学意义(P>0.05)。手术治疗后,卵巢癌患者血清HMGB1、VEGF表达水平显著降低,与治疗前比较,差异有统计学意义(P<0.05)。结论 HMGB1、VEGF在卵巢癌患者血清的表达水平可为疾病疗效判断和预后评估提供重要参考价值。

Objective To investigate the changes and clinical significance of serum levels of HMGB 1,VEGF before and after operation in patients with ovarian carcinoma .Methods The serum levels of HMGB1 and VEGF were detected by ELISA in 40 patients with ovarian cancer before and after operation ,60 patients with benign ovarian tumor and 30 healthy subjects.Results The serum levels of HMGB1 and VEGF were obviously increased in ovarian carcinoma group ,as compared with those in the other two groups （ P 〈0.05）.However there were no significant differences between normal control group and benign ovarian tumor group （ P 〈0.05）.After operation,the serum levels of HMGB1 and VEGF were significantly decreased in ovarian carcinoma group,as compared with those before treatment （ P 〈0.05）.Conclusion Detection of serum levels of HMGB1 and VEGF has important reference value for evaluating therapeutic efficacy and prognosis of patients with ovarian carcinoma.