圣愈汤加味联合大分割放射治疗骨转移癌的临床疗效及安全性研究

Research on Curative Effects and the Safety of Modified ShengYu Decoction Combined with Hyperfraction Radiotherapy in the Treatment for Metastatic Carcinoma of Bone

目的:探讨圣愈汤加味联合大分割放射改善骨转移癌患者的生存质量,提高治疗有效率的优势及安全性。方法:将骨转移癌患者90例随机分为3组,综合治疗组[圣愈汤加味联合大分割放疗(3 000 cGy/10次,1次/d,5次/周)]、大分割组、常规分割组,于4周后观察3组患者疗效及毒副反应。结果:综合治疗组、大分割组、常规分割组对骨转移癌痛缓解有效率分别为84.38%、82.14%、80.00%,3组比较差异无统计学意义(P>0.05),在中医证候明显改善率、生活质量提高率方面综合治疗组明显优于大分割组及常规分割组(P<0.05)。结论:圣愈汤加味联合大分割放疗治疗骨转移癌疗效确切,能明显提高患者生存质量。

Objective： To investigate the advantages of improving life quality and treatment effective rates and the safety of modifiedShengYudecoction and hyperfraction radiotherapy in treating metastatic carcinoma of bone. Methods： Ninety patients were randomized into three groups： comprehensive treatment group[modifiedShengYude-coction and hyperfraction radiotherapy （3 000 cGy each ten times, once per day, each week five times）], hyperfrac-tion radtiontherapy group and convention fraction group. Toxicity and curative effects of three groups were observed after treating for 4 weeks. Results： Pain remission effective rates of metastatic carcinoma of bone in comprehensive treatment group, hyperfraction radiotherapy group and convention fraction group were 84.38%, 82.14% and 80.00% respectively, the differences demonstrated no statistical meaning among three groups（P＆gt;0.05）, comprehensive treat-ment group was remarkably superior to hyperfraction radiotherapy group and convention fraction group in improve-ment rates of TCM symptom and life quality （P＆lt;0.05）. Conclusion： ModifiedShengYudecoction and hyperfraction radiotherapy could obtain definite effects in treating metastatic carcinoma of bone, and the therapy could improve life quality of the patients obviously.