薯蓣皂苷元抗肿瘤作用及其机制研究

Study on Anti-tumor Effects and the Mechanism of Diosgenin

从薯蓣皂苷元(Diosgenin,Dio)抗肿瘤作用、抗肿瘤作用机制方面综述近十年来国内外薯蓣皂苷元抗肿瘤作用及其机制研究进展,指出薯蓣皂苷元是一种天然的甾体皂苷,其来源广泛,具有调节免疫、抗肿瘤、抗炎等多种药理活性,其抗肿瘤活性引起了广大学者的关注,作用机制具有多靶点、多环节、多效应的特点,同时指出Dio对不同类型的肿瘤作用机制各有不同,研究深度各有差异,因此有必要利用现代分子生物技术对Dio在不同肿瘤中的作用及机制进行更全面更深入的研究;同时,针对Dio的抗肿瘤作用特点,联合其他抗肿瘤药物进行研究,将能更充分发挥传统中药在抗肿瘤方面的独特效用。

The paper is discussing the progress of anti-tumor effects and its mechanism ofdiosgenin （Dio） in recent ten years at home and abroad from the anti-tumor effects and its mechanism. Dio is a kind of natural steroidal saponin, and widely available, it shows pharmacological activities such as immunity-regulating, anti-tumor, anti-in- flammation, the anti-tumor activity had attracted the attention of many scholars, its mechanism demonstrates the fea- tures of multiple target points, multiple links and multiple effects, at the same time, the mechanisms of Dio fighting against different types of tumors are different, and their depths are different, therefore, it is necessary to study the ef- fects and its mechanisms completely with modem molecular biology; meanwhile, the studies centered on anti-tumor features of Dio and the combination with other anti-tumor drugs could fully develop the unique roles of traditional herbs fighting against the tumor.