奥美拉唑对喉软化患儿食管动力学的影响观察

Influence of omeprazole on the sophageal dynamics of children with laryngomalacia

目的探讨奥美拉唑对喉软化患儿食管动力学的影响,为该病的治疗提供依据。方法选取2009年4月—2013年2月于该院进行治疗的46例喉软化患儿为研究对象,将其随机分为对照组(常规方案治疗组)23例和观察组(常规方案加奥美拉唑治疗组)23例,然后将两组治疗6、12周的总有效率与治疗前后的食管动力学指标进行统计及比较。结果观察组治疗6、12周的总有效率分别高于对照组,治疗后的食管动力学指标也明显好于对照组,均P<0.05,有显著性差异。结论奥美拉唑对喉软化患儿食管动力学的影响较大,有助于患儿疾病治疗效果的改善。

Objective To study the influence of omeprazole on the sophageal dynamics of children with laryngomalacia,in order to pro- vide evidence for the treatment. Methods Forty-six children with laryngomalacia admitted to Shenzhen Children＇ s Hospital from April 2009 to February 2013 were selected as research objects ,and were randomly assigned into control group（ conventional therapy group ,n = 23 ） and observation group （conventional therapy plus omeprazole group, n = 23 ）. The total effective rate at 6 th and 12 th week after the treatment and sophageal dynamics indexes before and after the treatment of two groups were analyzed and compared. Results The total effective rates of observation group at 6 th and 12 th week after the treatment were respectively higher than those of control group, and sophageal dynamics indexes of observation group after the treatment were obviously better than those of control group （ P 〈 0. 05 ）, both with significant differences. Conclusions The influence of omeprazole on the sophageal dynamics of children with laryngomalacia is great, and it is helpful for the improvement of treatment effect of children.