炎琥宁对病毒性胃肠炎患儿炎性应激免疫状态的影响研究

Effects of Yanhuning on inflammatory stress and immunological status of infants with viral gastroenteritis

目的 探讨炎琥宁对病毒性胃肠炎患儿炎性应激及免疫状态的影响.方法 将82例病毒性胃肠炎患儿随机分为对照组和观察组各41例,两组均给予补液、退热、纠酸、调节菌群治疗,对照组静脉滴注利巴韦林10mg/kg·d,1次/d,疗程5-7d;观察组静脉滴注炎琥宁8-10mg/kg·d,1次/d,疗程5-7d.比较治疗前、治疗后3天和治疗后10天患儿血清细胞因子和细胞免疫指标的变化.结果 两组治疗后3天和10天的血清抗炎因子（IL-2、IL-4、IL-10）、促炎因子（IL-6、TNF-α）和细胞免疫指标（CD3^＋、CD4^＋、CD8^＋）较治疗前均明显改善（P＜0.05）,组间比较,观察组改善情况均明显优于对照组（P＜0.05）.结论 炎琥宁可明显改善病毒性胃肠炎患儿的炎性应激与免疫状态.

Objective To investigate the effects of Yanhuning on inflammatory stress and immunological status of infants with viral gastroenteritis.Methods 82 infants with viral gastroenteritis were randomly divided into control group （n=41） and observation group （n=41）.Both groups were given fluid replacement,fever treatment,acid correction and regulation flora.The control group was given 10mg/kg/d ribavirin by intravenous drip one time a day for five to seven days and the observation group was given 8-10mg/kg/d Yanhuning by intravenous drip one time a day for five to seven days.The serum cellular factors and cellular immunity of two groups before the treatment and at 3rd and10th day after the treatment were compared.Results The changes of serum anti-inflammatory factors（IL-2,IL-4 and IL-10）,pro-inflammatory factors（IL-6 and TNF-α）and cellular immunity（CD3 ^＋,CD4^＋ and CD8^＋）at 3rd and10th day after the treatment in two groups were all obvious better than that before the treatment（P〈0.05）and those of the observation group at 3rd and10th day after treatment were all obvious better than that of control group.Conclusion Yanhuning can obvious improve inflammatory stress and immunological status of infants with viral gastroenteritis.