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精神分裂症高危人群脑白质弥散张量成像研究 被引量：5

Diffusion Tensor Imaging Study in White Matter of Ultra-high-risk for Psychosis
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摘要 目的:应用磁共振弥散张量成像(DTI)技术,观察精神分裂症高危人群(UHR)脑白质的改变。方法:对15例UHR和17例正常对照进行脑部DTI扫描后,采用基于纤维的空间统计方法(TBSS),比较全脑的各向异性分数值(FA值)。结果:UHR组平均FA值低于对照组,差异有统计学意义(P<0.05);UHR组与对照组有差异的脑白质位于左侧额叶和左侧内囊前肢。结论:精神分裂症高危人群存在脑白质微结构的改变。 Objective： To use diffusion tensor imaging （diffusion tensor imaging, DTI） technology to investigate the abnormal changes in white matter of ultra-high-risk for psychosis （UHR）. Method： 15 cases of UHR and 17 cases of normal controls underwent a DTI scan,tract-based spatial statistics（TBSS） was performed to measure the fractional anisotropy （FA） of the whole brain.Result： FA mean values of the UHR group was lower than that in the control group, the difference was statistically significant（P〈0.05）; there are differences in the two groups of white matter in the left frontal lobe and the left anterior limb of internal capsule.Conclusion：The microstructural of whole-brain white matter was altered in ultra-high-risk for psychosis.
作者 王秀霞 田峰 徐勇 赵婷 郭晓杰
机构地区 山西医科大学第二临床医学院 山西医科大学第二医院 山西医科大学第一医院
出处 《中国医学创新》 CAS 2014年第13期21-23,共3页 Medical Innovation of China
基金 国家自然科学基金(81278412)
关键词 弥散张量成像 各向异性分数 脑白质 精神分裂症高危人群 Diffusion tensor imaging Fractional anisotropy White matter Ultra-high-risk for psychosis
分类号 R749.3 [医药卫生—神经病学与精神病学]
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参考文献15

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二级参考文献15

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共引文献5

同被引文献30

引证文献5

二级引证文献16

中国医学创新
2014年 第13期

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