全膝关节置换术后自体引流血回输有效性及安全性的Meta分析

A meta-analysis on the efficacy and safety of autologous drainage blood reinfusion in total knee arthroplasty

目的:本研究评价自体引流血回输对全膝关节置换术有效性及安全性的影响。方法:计算机检索数据库MEDLINE、PubMed、Cochrane图书馆、中国生物医学光盘数据库等数据库,收集全膝关节置换术后使用自体引流血回输装置和负压吸引装置不回输的对照试验,采用统计软件RevMan5.1进行分析。结果:共纳入8个临床对照研究,其中回输组318例,对照组322例。结果显示自体引流血回输能够减少全膝关节置换患者术后异体血输血量和异体血输血率及平均住院时间,而深静脉血栓、切口感染发生率差异无统计学意义。结论:自体引流血回输是一种安全有效、节约血源及财力的方式,可减少异体输血量和住院时间,避免出现并发症。

Objective To assess the efficacy and safety of autologous drainage blood reinfusion in total knee arthroplasty（TKA）. Methods Computers were used to search the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and VIP. The randomized controlled trials（RCTs） of autologous drainage blood reinfusion and vacuum suction without reinfusion after TKA were collected. And the results were analyzed by using the software RevMan5.1. Results Eight RCTs met the criteria for meta-analysis. Use of autologous drainage blood reinfusion significantly reduced the average amount of units of homologous blood transfusion, the length of hospital stay, and the number of patients requiring homologous blood transfusion. The rates of DVT formation and incision infection did not differ significantly between the two groups. Conclusions Autologous drainage blood reinfusion is a safe, effective procedure with less blood transfusion and medical cost. It can lower volume of allogeneic blood transfusion, shorten length of hospital stay, and avoid occurrence of complications.