调强放射治疗联合黄芪多糖注射液治疗头颈部肿瘤的临床疗效

Clinical observation of IMRT therapy combined with astragalus polysaccharide injection on cervicoce-rebral tumor treatment

目的:观察适形调强放射治疗联合黄芪多糖注射液治疗头颈部肿瘤的疗效、免疫力情况及毒副反应的临床研究。方法:观察61例初治头颈部肿瘤患者随机分为适形调强放疗联合黄芪多糖组(30例)和适形调强放疗组(31例),观察并比较两组近期疗效、免疫力情况及毒副反应,放疗前后T细胞亚群、自然杀伤(NK)细胞活性的变化,以及观察放疗中、后患者出现的皮炎及口腔黏膜反应、口干等情况。结果:实验组和对照组的总有效率分别为83.0%和80.6%。适形调强放疗联合黄芪多糖组外周血淋巴细胞及NK细胞活性增高,T3、T4、NK细胞值增高(P<0.05),对照组治疗前后外周血T3、T4、NK细胞值降低(P<0.05),黏膜反应和皮炎、口干在治疗3周后实验组明显好与对照组(P<0.05)。结论:黄芪多糖可以可以提高患者机体的免疫水平,降低适形调强放射治头颈部肿瘤患者放疗的副作用。

Objective To observe the effect of IMRT combined with astragalus polysaccharide（ASP） injection on cervicocerebral tumor,radiation side effects and its influence on immune function. Methods 61 head and neck tumor patients were randomly divided into two groups.One groups received the IMRT combined with Astragalus Polysaccharide（ASP） injection（n=30） while the other group only received the IMRT（n=31）. The recent effect, immune function and the side effects of radiotherapy between the 2 groups were observed and compared, changes of T-lymphocyte subsets, natural killer（NK） cell activity and the dermatitis,oral mucosa reaction,thirsty condition on patients in intraoperative or postoperative period were also observed and compared. Results The total effective rate in experimental group and the control group were 83.0% and 80.6% respectively.The cell viability of peripheral blood lymphocyte and NK cell as well as the T3 、T4、NK cell value increased in IMRT-ASP group（P〈0.05） after treatment. While T3、T4、NK cell value in peripheral blood decreased（P〈0.05）. Mucosa,dermatitis and salivary gland damage showed in IMRT-ASP group were significantly better than in control group after 3 weeks treatment（P〈0.05）. Conclusion ASP can improve immune function effect in head and neck tumor patients during RT, and can also eliminate the side effects of radiotherapy.