Bcl-w和PDCD5在前列腺增生和前列腺癌组织细胞中的表达及相关性

Expressions of bcl-w and PDCD5 in tissues of BPH and prostate cancer

目的 研究凋亡相关基因Bcl-w和PDCD5在前列腺癌（PCa）、良性前列腺增生（BPH）和正常前列腺（NP）组织中表达的相关性及其意义.方法 通过免疫组织化学法检测10例NP、25例BPH及25例PCa组织切片Bcl-w和PDCD5的表达.结果 NP组、BPH组、PCa组Bcl-w染色阳性率分别为20％、36％、64％;NP组,BPH组,PCa组PDCD5染色阳性率分别为80％、68％、28％.将Bcl-w蛋白和PDCD5蛋白在不同病例组织中的染色强度指数（staining intensity index,SII）做进一步的Pearson直线相关性分析,提示在NP、BPH以及PCa癌组织中,Bcl-w SII和PDCD5 SII呈负相关（r=-0.904,P＜0.05）.结论 不论Bcl-w的过度高表达,还是PDCD5的低表达都与前列腺癌的发病相关,Bcl-w和PDCD5在前列腺癌的发生与发展中可能互相影响.这两项指标可作为辅助检测前列腺癌变的基因标志物.

Objectives To study the relationship of the expressions of apoptosis-related gene Bcl-w and PDCD5 in tissues of prostate cancer（PCa）,BPH and normal human prostate（NP）.Methods The expressions of Bcl-w and PDCD5 were observed separately in 10 normal human prostate（NP）,25 of BPH,and 25 of prostate cancer（PCa） by Immunohistochemical means.Results Bcl-w positive rate in normal human prostate（NP） was 20％,in BPH was 36％,and in prostate cancer（PCa） was 64％.PDCD5 positive rate in normal human prostate （NP） was 80％,in BPH was68％,and in prostate cancer（PCa） was 28％.There was a negative relationship between Bcl-w SII and PDCD5 SII in every lesion.Conclusions It suggests that both Bcl-w and PDCD5 could be used as molecular markers of carcinogenesis for prostate cancer（PCa）.