氧化低密度脂蛋白在维持性血液透析患者中的检测及意义

The levels and role of oxidized low density lipoprotein in maintenance hemodialysis patients

目的 探讨维持性血液透析患者血浆氧化低密度脂蛋白（ox-LDL）的水平及其意义.方法 对本院维持性血液透析患者66例及健康志愿者22例,用ELISA法测定血浆ox-LDL水平,用全自动生化仪测定血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、血肌酐（Scr）与血白蛋白（ALB）值.比较其结果并分析其意义.结果 血液透析组血浆ox-LDL水平（4176.9±2038.6μg/L）明显高于对照组（326.9±173.8μg,/L）,其差异有统计学意义（P=0.003）.血液透析合并冠心病组血浆ox-LDL水平（5021.3±2873.9μg/L）明显高于非合并冠心病组（3163.7±1430.2μg/L,P=0.018）.结论 慢性肾衰竭血液透析患者血浆ox-LDL水平显著高于正常人,而合并冠心病患者血浆ox-LDL水平更高,提示ox-LDL水平升高与肾功能衰竭有一定关系,且可能是合并冠心病的重要危险因素.

Objectives To explore the plasma level and role of oxidized low density lipoprotein （ox-LDL） in maintenance hemodialysis patients.Methods Plasma ox-LDL was measured by sandwich ELISA and the serum total cholesterol,triglyceride,high density lipoprotein-cholesterol,low density lipoprotein-cholesterol,serum creatinine,blood albumin of 66 hemodialysis patients in our hospital were determined and compared with those of 22 healthy controls.Results The plasma levels of ox-LDL was obviously elevated in hemodialysis patients （4176.9μg/L ±2038.6μg/L） compared with control subjects（326.9μg/L ± 173.8μg/L）,the differences had statistical significance（P =0.003）.And it was higher in hemodialysis patients with coronary heart disease （5021.3μg/L ±2873.9μg/L） than that in hemodialysis patients without coronary heart disease （3163.7μg/L ± 1430.2μg/L） （P =0.018）.Conclusions Ox-LDL level in maintenance hemodialysis patients was higher than control subjects and it was even higher in hemodialysis patients with coronary heart disease.It indicated that the increase of ox-LDL may be concerned with renal failure and an important risk factor of coronary heart disease.