输尿管结石术后医院感染的病原菌及其耐药性分析

Analysis of distribution and drug resistance of pathogens in ureteral calculi patients with postoperative infection in urology surgery department

目的探讨泌尿外科输尿管结石术后患者发生的病原菌感染及耐药性,为临床防治提供指导性建议。方法对2008年3月-2012年12月在泌尿外科行手术治疗后出现医院感染的203例输尿管结石患者,回顾性分析其临床资料,并采集标本进行病原学培养、分离,进行药敏试验。结果共分离出276株病原菌,其中大肠埃希菌检出率为31.5%,显著高于其他病原菌的检出率;分析大肠埃希菌和金黄色葡萄球菌对常用抗菌药物的耐药性,结果 0株大肠埃希菌对亚胺培南耐药,耐药率为0.0%,与对其他抗生素的耐药率比较差异有统计学意义;对亚胺培南耐药的金黄色葡萄球菌仅2株,耐药率为4.0%,与其他抗生素比较差异有统计学意义。以上均P<0.05。结论泌尿外科输尿管结石术后患者发生医院感染的病原菌分布以大肠埃希菌及金黄色葡萄球菌为主,2种细菌均对亚胺培南有较低的耐药率。

Objective To discuss the distribution and drug resistance of pathogens in ureteral calculi patients with postoperative infection in urology surgery department and to provide guidance and advice for clinical treatment. Methods From March 2008 to December 2012,203 ureteral calculi patients with postoperative infection in the hospital were selected for retrospective analysis of the clinical information,and the specimens were collected from these cases for culture,isolation and drug sensitivity test. Results A total of 276 pathogen strains were isolated,and Escherichia coli accounted for 31. 5%,significantly higher than other pathogens. Drug resistance analysis showed that no Escherichia coli was found resistant to imipenem,the drug resistance rate was 0%,there was significant difference in drug resistance when compared with the other antibiotics（P〈0. 05）; While only 2 strains of Staphylococcus aureus were found resistant to imipenem,the drug resistance rate was 4%,there was also significant difference in drug resistance when compared with the other antibiotics（P〈0. 05）. Conclusion Escherichia coli and Staphylococcus aureus were the main pathogens in postoperative infection of ureteral calculi patients in urology surgery department,and both showed lower drug resistant rate to imipenem.