高龄脑小血管病患者脑微出血与步态障碍的相关性分析

Correlation between microbleeds and gait disorders in elderly patients with cerebral small vessel disease

目的探讨高龄脑小血管病患者脑微出血病灶与步态障碍的关系。方法选择80岁以上军队离退休男性脑小血管病患者232例,通过测量定量步态参数及临床步态量表、脑微出血病灶影像学检查和统计学分析,比较脑微出血病灶数目及部位与步长、步速、步宽等步态特征的相关性。结果脑微出血数目与步长(回归系数=-0.02,P=0.03)、步宽(回归系数=0.21,P=0.04)、Tinetti试验(回归系数=-0.19,P=0.00)及起立行走试验(回归系数=0.02,P=0.02)比较,差异有统计学意义。脑叶和深部微出血灶与步长、步宽呈负相关,与Tinetti试验及站立行走试验的相关性差异有统计学意义(P<0.05,P<0.01)。结论脑微出血作为独立因素和高龄脑小血管病患者的步态障碍有相关性。

Objective To study the correlation between microbleeds and gait disorders in elderly patients with cerebral small vessel disease.Methods Two hundred and thirty-two elderly veterans（≥80years old）with cerebral small vessel disease were included in this study.Their gait parameters and microbleed foci were detected.Correlation of the number and location of microbleeds with gait features including stride length and width was analyzed.Results The number of microbleeds was positively related with the stride length and width and gait score（P〈0.05,P 〈0.01）while the lobar and deep microbleeds were negatively related with the stride length and width and gait score（P〈0.05,P〈0.01）.Conclusion Microbleeds are related with gait disorders in elderly patients with cerebral small vessel disease.