影响米非司酮配伍米索前列醇终止早孕效果的因素分析

Factors affecting mifepristone and misoprostol efficacy in the termination of early pregnancy

目的:探讨多因素对米非司酮配伍米索前列醇终止早孕时的影响。方法:回顾312例早孕产妇经米非司酮配伍米索前列醇治疗终止早孕的效果。分析并比较药物流产与孕次、产次、体重、妊娠天数及剖宫产史的结果。结果:孕次的增加,流产失败率逐渐提高,但无显著差异(P>0.05);产次与流产结果组间比较,各组间无显著差异(P>0.05);体重>55kg组与其它两组比有显著性差异(P<0.05);孕龄大于46d或等于49d均有显著性差异(P<0.05)。流产成功率与有无剖宫产史两组比较无明显差异(P>0.05)。结论:孕次、产次、体重、妊娠天数及剖宫产史对药物流产的影响不大,米非司酮配伍米索前列醇终止早孕,方法简便,成功率及安全性高,适合在基层推广。

Objectives：To investigate the factors affecting mifepristone and misoprostol efficacy in the termination of early pregnancy.Method：312 cases with mifepristone and misoprostol termination of early pregnancy were reviewed and analyzed to compare the efficacy in terms of pregnancy times,weight,gestational days and the results of cesarean delivery.Results：With the times of pregnancy increased,the abortion failure rate also increased,but without significant difference（P〉0.05）;Weight〉55kg group showed significant difference from other groups（P〉0.05）;more than 46d or equal to 49d also showed significant differences（P〈0.05）.There was no significant difference between success rate of abortion and history of cesarean section（P 〉0.05）.Conclusion：Gravidity,body weight,gestational days and history of cesarean section have little effect on medical abortion.Mifepristone and misoprostol in termination of early pregnancy have higher success rate and safety rate.It can be an effective method in the termination of early pregancy.