不同年龄段妇女卵巢储备功能的对比研究

Color Doppler ultrasound measurement of ovarian volume,number of follicles and ovarian reserve function

目的：探讨不同年龄段妇女的卵巢储备功能的变化规律。结果：20～29岁年龄段患者的窦卵泡数量最多、卵泡体积最大,明显高于其他三组（P〈0.05）;≥40岁组卵泡数量及卵泡体积在整个月经周期里无明显变化（P〉0.05）,窦卵泡数量明显少于其他组（P〈0.05）;各年龄段血流频谱成周期性变化,且滤泡期和黄体期PI、RI、S/D值明显高于排卵期（P〈0.05）,但滤泡期与黄体期比较,无统计学差异（P〉0.05）;≥40岁组各期PI、RI、S/D值明显高于20～29岁组和30～39岁组。结论：女性卵泡体积、数量以及排卵率随年龄增长呈逐渐降低趋势。

Objectives： To explore the application value of transvaginal color Doppler ultrasound in the measurement of ovarian volume and the number of follicles and ovulation in infertile women. Methods： 75 cases of infertile women with normal menstrual cycle and 23 cases of women were selected as the research object,the normal menstrual cycle in women by age was 20- 29 years old,and 30- 39,≥ 40 years old group,all patients with antral follicle,volume of ovary and ovarian stromal blood flow examination was examined with doppler ultrasound,and the relationship between and ovarian reserve and infertility were analyzed. Results： the 20- 29 age group had the largest number of antral follicle and follicle size,significantly higher than the other 3 groups（ P〈0. 05）; the follicle number and follicular volume of 40 years of age or older group did not change significantly throughout the menstrual cycle（ P〉0. 05）,while their antral follicle number was significantly less than the other groups（ P〈0. 05）; the follicle number and the normal menstrual cycle of infertility patients were not significantly different,but the size of follicles was smaller than the normal menstrual cycle group（ P〈0. 05）; the normal menstrual blood flow spectrum in each age group demonstrated periodic variation,and the follicular phase and luteal phase of PI,RI,S / D value was significantly higher than that of ovulation（ P〈0. 05）,but comparison of the follicular phase and luteal phase between the 2 groups was of no significant difference（ P〉0. 05）; the PI,RI,S / D of 40 years old or older patients was significantly higher than that of 20- 29 years old age group and 30- 39 group; infertility patients with ovarian stromal artery blood flow spectrum of PI,RI,S / D in the follicular phase,no significant differences in ovulation and luteal phase（ P〉0. 05）,non periodic variation; 20- 29,30- 39,≥ 40,infertility group ovulation rate was 68. 6%（ 24 /35）,47. 8%（ 11 /23）,23. 5%（ 4 /17）,26. 1%（ 6 /23）. Conclusion： The normal application of color Doppler ultrasound technique in the measurement of follicle number,ovarian volume combined with ovarian stromal artery flow spectrum is also reflected in a certain degree of ovarian reserve,providing strong evidence for the diagnosis and differential diagnosis of infertility patients.