超敏C反应蛋白水平与急性脑梗死病情的相关性

Relationship between the high sensitivity C reactive protein level and the situation of the acute cerebral infarction

目的观察急性脑梗死患者血清超敏C反应蛋白水平与病情发展及演变的关系。方法急性脑梗死患者(151例)作为试验组,依据神经功能缺损程度再分为轻、中、重型3个亚组;选取健康者作为对照组(151例)。试验组进行常规治疗(低分子右旋糖酐250 mL连续7 d、丹红注射液4 mL连续14 d、5%碳酸氢钠250 mL连续3 d;视情况予以肝素总量不超过12500 u抗凝)。2组均进行血清超敏C反应蛋白(hs-CRP)、D-二聚体及低密度脂蛋白胆固醇(LDL-C)水平监测。比较2组血清hs-CRP水平与急性脑梗死严重程度的关系。结果急性脑梗死患者,血清hs-CRP水平、D-二聚体阳性率均明显高于对照组(P<0.05);其hs-CRP与神经系统损伤评分呈高度正相关(P<0.05);其D-二聚体水平与神经系统损伤评分也呈正相关(P<0.05)。结论 hs-CRP水平可以独立反映脑梗死疾病的发生发展,与病情有相关性。

Objective To investigate the relationship between the serum high - sensitivity C - reactive protein level and the situation of the acute cerebral infarction. Methods The trial group was made up of 151 diag- nosed patients with acute cerebral infarction in our hospital and in ac- cordance with the degree of neurological deficit score, they were divided into light, medium and heavy - duty groups. Patients in the trial group were given intravenous dextran 250 mL for 7 consecutive days, Danhong injection 250 mL for 14 days, 5% sodium bicarbonate 250 mL for 3 con- secutive days, and depending on the patient＇s condition, no more than 12,500 units of heparin were given. The control group were 151 random samples from the hospital medical center health personnel. The serum high- sensitivity C- reactive protein, D- dimer and low -density lipo- protein -C （LDL- C） level monitoring in both groups were carried out. Then the two groups were compared. The relationship between serum high - sensitivity C - reactive protein level and severity of acute cerebral infarction was analyzed. Results The positive rate and serum levels with serum hypersensitive C - reactive protein and D - dimer in patients with acute cerebral infarction were higher than those of the control group, with statistical difference （ P 〈 0. 05 ）. Hs CRP and nervous system damage score were high positive correlation （ P 〈 0. 05 ）. D - dimer level score was positively correlated with nervous system damage （P 〈 0.05 ）. Conclusion The high sensitivity C - reactive protein level can reflect the incidence and development of cerebral dis- ease independently, and the disease associated with prognosis and close monitoring of high sensitivity C - reactive pro- tein level on the prognosis of significance.