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几种蛋白检测在水泡状胎块病理诊断与分型中的价值 被引量：2

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摘要 目的:探讨几种蛋白检测在水泡状胎块(HM)病理诊断与分型中的价值。方法:应用组织芯片及免疫组织化学标记技术,对65例完全性水泡状胎块(CHM)、22例部分性水泡状胎块(PHM)、40例绒毛水肿(HA)共计127例病理组织标本检测p57kip2、CD34、p53、CD117及EGFR的表达。结果:p57kip2在PHM及HA中为阳性表达,在CHM中为阴性表达;CD34在CHM、PHM及HA各组中血管改变情况的评分结果分别为(2.79±0.44)、(2.86±0.36)和(1.23±0.80),在HM组与HA组之间比较差异有统计学意义(P<0.05),在CHM组与PHM组之间比较差异无统计学意义(P>0.05);p53在CHM、PHM及HA各组的评分结果分别为(1.12±0.76)、(0.91±0.53)和(0.65±0.74),在CHM组与HA组之间比较差异有统计学意义(P<0.05),在CHM组与PHM组及PHM组与HA组之间比较,差异均无统计学意义(P>0.05);CD117、EGFR在各组绒毛组织中均为阴性表达。结论:p57kip2、CD34、p53的免疫组织化学检测对于HM的诊断及分型具有重要价值,可作为客观指标应用于临床病理诊断。
作者 张燕 王一 王建华
机构地区 上海市普陀区妇婴保健院病理科
出处 《中国妇幼保健》 CAS 北大核心 2014年第15期2446-2449,共4页 Maternal and Child Health Care of China
基金 上海市卫生局科研课题〔2009244〕
关键词 水泡状胎块 P57KIP2 CD34 P53 免疫组织化学
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献17

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二级参考文献10

共引文献3

同被引文献17

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中国妇幼保健
2014年 第15期

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