糖尿病肾病的发病机制及抗糖尿病肾病化合物的研究进展

Research advances in the pathogenesis of diabetic nephropathy and the development of anti-diabetic nephropathy agents

糖尿病肾病(diabetic nephropathy,DN)是糖尿病最常见的并发症之一。近年来,随着世界范围内糖尿病患病率的上升,DN已成为威胁人类健康的一大杀手。DN的发病机制十分复杂。越来越多的研究表明,在个体差异的基础上,高血糖、高血压等引发的氧化应激、炎症反应和纤维化过程在DN的发生发展中起到了重要作用。因此,简单地控制高血糖、高血压、高血脂以及限制蛋白的摄入等基础治疗已经不足以控制DN的发生发展,针对氧化应激、炎症反应及纤维化等DN病理过程的药物开发将是抗DN药物研究的重点。本文就DN的发病机制及针对发病机制的抗DN化合物的结构、构效关系进行了综述。

In recent years,with the worldwide increase in the prevalence of diabetes,diabetic nephropathy（DN）,a complication of diabetes,has become a threat to human health and a major killer of human life. With research progress,it turns out that the pathogenesis of DN is very complicated. Besides the basis of individual differences,oxidative stress induced by high blood sugar or high blood pressure is a key link for two important factors, inflammation and fibrosis in the pathogenesis of DN. Therefore,in terms of the treatment of DN,simple control of blood sugar or other incentives has been insufficient to cope with the development. All the multiple links,such as oxidative stress,inflammatory and fibrosis should be considered in the process of drug discovery. In this paper,we summarized the pathogenesis of DN and a series of available anti-DN agents targeting at the pathogenesis.