高毒力肺炎克雷伯菌表型与基因型特征研究进展

Progress on phenotypic and genotypic characteristics of hypervirulent Klebsiella pneumoniae

肺炎克雷伯菌是临床重要的感染病原菌之一,其中高毒力肺炎克雷伯菌（hvKP）常引起化脓性肝脓肿.目前,有关hvKP的鉴定方法尚无统一标准.hvKP菌株通常具有高黏性,以K1 、K2血清型和CC23、CC65克隆型为主.rmpA、magA、alls和kfu等基因对于hvKP菌株的毒力特征具有显著作用.此文就hvKP的菌株鉴定、菌株克隆与血清型、高黏性特征和其他毒力相关基因等研究进展进行了综述.

Klebsiella Pneumoniae is an important pathogen for various infections clinically,in which hypervirulent Klebsiella pneumoniae （hvKP） mainly causes pyogenic liver abscess.By now,there are no standardized method to identify hvKP strains.hvKP strains are usually with hypermucoviscous phenotype,and the prevailing serotypes and clonal types are K1,K2 and CC23,CC65,respectively.Genes rmpA,magA,alls and kfu contribute to the pathogenicity of hvKP.This paper reviews the identification,clonal types and serotypes,hypermucoviscous phenotype and some other virulent genes of hvKP.