重症手足口病发病机制及治疗研究进展

Research progress on pathogenesis and treatment of severe hand, foot and mouth disease

重症手足口病病例主要由肠道病毒71型（EV71）感染引起,致死的主要原因是脑干脑炎和神经源性肺水肿.手足口病的治疗需要根据患者所处疾病分期采取不同策略,主要包括针对病原的抗病毒治疗和出现心肺功能受累后的处理.大多数患者随着病情好转后神经系统损害逐渐减轻并痊愈,少数危重病例可能存有后遗症.此文对近年来重症手足口病的发病机制及治疗等相关研究进展作了综述.

It has been revealed that most patients with severe hand,foot and mouth diseases are infected with enterovirus 71 （EV71）.The death usually occurs with brain stem encephalitis and neurogenic pulmonary edema.Treatment of hand,foot and mouth disease should be stage-based,mainly includes antivirus treatment and management of impaired cardiopulmonary functions.Neurological damage may regress or disappear with disease recovery in most children,but sequelae may also exist in a few critical cases.This paper reviews the research progress on pathogenesis and treatment of severe hand,foot and mouth diseases.