牙周炎与患者机体代谢综合征的相关性及中药治疗的临床效果

Correlation between periodontitis and metabolic syndrome and discussion on traditional Chinese medicine in treatmentof periodontitis

目的统计学分析牙周炎患者机体代谢综合征指标,探讨牙周炎与代谢综合征的相关性及中药治疗的临床效果。方法选取符合牙周炎诊断标准并愿意接受20 d中药治疗的患者140例为研究对象,按照牙周炎的严重程度分为轻度牙周炎组70例和中重度牙周炎组70例。同时选取符合牙周炎诊断标准的并仅接受西药治疗的患者140例,同样分为轻或中重度牙周炎组,各70例。比较4组患者血压(SBP和DBP)、血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,应用Logistic多因素回归分析探讨牙周炎与代谢综合征的相关性。观察中药方剂治疗前后牙周炎患者机体代谢综合征的变化情况,明确相关指标与牙周炎的关系。结果 4组牙周炎患者TG、HDL-C及FPG等3指标间的比较具有显著性差异(P<0.05),DBP及TC间的差异无显著性;中西药治疗法在中重度牙周炎患者中的疗效差异具有显著性;中药显效的患者机体代谢综合征指标SBP、FPG、TC、TG、LDL-C均低于治疗前,HDL-C水平较治疗前高,差异有显著性(P<0.05)。结论牙周炎的严重程度与患者机体代谢综合征指标间具有一定的相关性,中药治疗牙周炎的效果显著优于西药。

[ Objective ] To analyze the metabolic syndrome indicators of periodontitis patients and to investigate the correlation between periodontitis and metabolic syndrome and the efficacy of Chinese medicine. [Methods] 140patients who were consistent with the diagnostic criteria of periodontitis were selected in this study, All of them were willing to be treated with herbal medicine with 20 days. They were divided into two groups according to the severity of periodontitis： mild periodontitis group with 70 cases and severe periodontitis group with 70 cases. The control group was composed of 140 patients who were consistent with the diagnostic criteria of periodontitis. All objects in the control group were only treated with western medicine. The control group was divided into two groups too：mild periodontitis group with 70 cases and severe periodontitis group with 70 cases. SBP, DBP, FPG, TG, HDL- C and TC were compared in different groups. Logistic regression was applied for the correlation between periodontitis and metabolic syndrome. Changes of metabolic syndrome before and after treatment were observed. [ Results ] It was showed by the results of comparison with metabolic syndrome indicators between 4 groups of periodontitis patients that TG, HDL-C, and FPG had significant difference （P 〈0.05）; DBP and TC were not statistically significant. Efficacy of herbal and western medicine treatment method wasextremely better in severe periodontitis group. SBP, FPG, TC, TG, LDL-C in patients for whom Chinese medicine is effective were lower than before treatment, but value of HDL-C level was higher. The difference was statistically significant（P 〈0.05）.[ Conclusions] There is a correlation between periodontitis and metabolic syndrome. The effect of traditional Chinese medicine treatment of periodontitis was significantly better than western medicine.