乳腺、肾多原发恶性肿瘤一例并文献复习

One case of breast,kidney multiple primary malignant neoplasms and the review of literature

目的：探讨多原发恶性肿瘤的病因、临床特点、诊治及预后。方法分析郑州大学附属肿瘤医院内科收治的1例乳腺、肾多原发恶性肿瘤患者的临床资料，并对其发生率、临床特点、诊断、治疗及预后进行相关文献复习。结果多原发恶性肿瘤发生率低，乳腺、肾多原发恶性肿瘤更是罕见，临床易造成漏诊和误诊。结论多原发恶性肿瘤病因可能与遗传、放化疗等因素有关；在首发癌治疗的同时，应警惕其他原发癌发生的可能；加强对其认识，做到早期诊断、早期规范化的个体治疗，可延长生存期、改善预后。

Objective To investigate the etiology,clinical features,diagnosis,therapy and prognosis of multiple primary malignant neoplasms（ MPMNs）. Methods The clinical data of one case of breast,kidney multiple primary malignant neoplasms,which was treated in our department were analyzed,and the literatures related to its incidence,clinical features,diagnosis,therapy and prognosis were reviewed. Results MPMNs had low incidence rate,and breast and kidney multiple primary malignant neoplasms was rare. MPMNs was prone to be misdiagnosed. Conclusions MPMNs may be related to hereditary factors,chemotherapy and radiotherapy. While curing the first cancer,we should be aware of the possibility of MPMNs. Strengthen the understanding of MPMNs,ensure the early diagnosis and standardized individual treatment, can prolong the survival and improve the prognosis of MPMNs.