阿托伐他汀对颈动脉内膜剥脱术后再狭窄的预防作用

Preventive effect of atorvastatin on postoperative restenosis of carotid endarterectomy

目的：探讨颈动脉内膜剥脱术（ CEA）后患者长期口服阿托伐他汀对颈动脉再狭窄的预防作用。方法回顾性分析郑州大学第五附属医院2010年1月至2012年3月84例成功行CEA患者的临床资料及随访资料，62例患者长期服用阿托伐他汀，22例未服用他汀类药物，随访12个月，观察患者术后1年颈动脉通畅情况及血脂水平情况，评估阿托伐他汀对CEA术后再狭窄的预防效果。结果服用阿托伐他汀患者血总胆固醇、低密度脂蛋白均较未服用他汀药物患者低，高密度脂蛋白较未服用阿托伐他汀患者高，差异均有统计学意义（P〈0.05）；服用阿托伐他汀患者再狭窄患者7例，未服用阿托伐他汀患者再狭窄患者7例，其中闭塞2例，差异有统计学意义（P〈0.05）。结论阿托伐他汀对CEA术后患者颈动脉再狭窄有良好的预防作用。

Objective To evaluate the preventive effect of atorvastatin on postoperative resteno-sis of carotid endarterectomy（ CEA）. Methods From January 2010 to March 2012,a total of 84 pa-tients who underwent CEA were enrolled in the study,62 patients took atorvastatin and 22 patients didn’t take any statins,and they were followed up for 12 months. The patency of carotid artery and the level of blood lipid was observed,and the preventive effect of atorvastatin on restenosis after CEA was evaluated. Results The levels of blood total cholesterol（ TC）and low-density lipoprotein（ LDL）of patients who took atorvastatin were lower than those in the patients who didn’t take atorvastatin,and the level of high density lipoprotein（ HDL）was relatively higher than that in patients didn’t take atorvastatin,the differences were significant（ P〈0. 05 ）. There were both 7 patients with restenosis in patients who took atorvastatin and didn’t take atorvastatin,and 2 patients with carotid artery occlusion in patients who didn’t take atorvastatin,there was significant difference. Conclusions Atorvastatin has positive preventive effect on postoperative carotid artery restenosis of patients with CEA.