244对有不良孕产史夫妇初次染色体断裂率检测结果分析

The chromosome breakage rates in 244 cases of the infertility couples

为了了解有不良孕产史夫妇的染色体断裂率的发生情况,笔者对来河南省人口和计划生育科学技术研究院就诊的有不良孕产史夫妇的染色体断裂率分析的检查结果进行统计学分析。分析结果显示:男性患者的就诊年龄平均为29.07岁,女性患者的就诊年龄平均为28.15岁,年龄与染色体检测结果间无相关。男性患者中未发现断裂的占男性总数的32.38%,女性患者中未发现染色体断裂的占女性总数的37.7%;男性染色体断裂率为1的占男性总数的38.11%,女性染色体断裂率为1的占女性总数的34.43%;男性染色体断裂率为2的占男性总数的21.72%,女性染色体断裂率为2的占女性总数的23.36%;男性染色体断裂率为3的占男性总数的7.79%,女性染色体断裂率为3的占女性总数的2.87%;女性染色体断裂率为4的占女性总数的0.82%;女性染色体断裂率为6的占女性总数的0.41%;女性染色体断裂率为9的占女性总数的0.41%。男性患者的染色体断裂率均值无差别(P>0.05)。男、女患者的染色体断裂率均值在1.01,患者平均年龄为29.53岁,经检查有染色体断裂占64.96%。通过研究发现,染色体断裂率增高可能是引起夫妇中发生胎停、流产、胎儿发育不良等不良孕产现象的重要原因之一。

To understand the incidence of chromosome breakage rates for the adverse pregnancy history in the infertility couples,we analyzed statistically the chromosomal breakage rates in the infertility couples which have adverse pregnancy history. The results show that： The male patients average age was 29.07,the female patients average age was 28.15,their age and chromosome breakage showed no correlation. The male patients have founded no breakage accounted for 32.38 % of the total in the male patients,the female patients found no chromosome breakage accounted for 37.7 % of the total number of females patients;they have 1 % of breakage rates accounted for 38.11 % of the total in the male cases and the female patients were 34.43 %;they have 2 % of breakage rates which accounted for 21.72 % in total male cases and the female were 23.36 %;they have 3 % of chromosome breakage rates which accounted for 7.79 % in the male cases and the female were 2.87 %;they have 4 %,6 % and 9 % of the chromosome breakage rates that accounted respectively for 0.82 %,0.41 %,0.41 % in total female. The chromosomal breakage rates in the male patients and female no difference（P〉0.05）. The average chromosome breakage rates were 1.01,their average age was 29.53 and the chromosome breakage rates were 64.96 % in the total cases. The increased rates of chromosomal breakage may be one of the important reasons for embryo damage、miscarriage and other the adverse pregnancy in the infertility couples.