钙离子拮抗剂尼伐地平的波谱学解析与结构确证

Spectral analysis and structural elucidation of calcium antagonist nilvadipine

目的对钙离子拮抗剂尼伐地平进行系统的波谱学解析与结构确证。方法运用热分析、圆二色谱、紫外光谱、红外光谱、核磁共振、质谱、高分辨率质谱以及X射线粉末衍射等分析手段测定样品的谱学数据,并进行系统解析与归属。结果证实尼伐地平的结构为3-甲基-5-(1-甲基乙基)-4-(RS)-2-氰基-6-甲基-4-(3-硝基苯基)-1,4-二氢吡啶-3,5-二羧酸酯。结论本法测定结果准确,为尼伐地平的生产和鉴定提供较为全面的参考数据。

Objective To determine the chemical structure of nilvadipine with systematic spectrum analysis. Methods TG-DSC, CD, UV, FT-IR, NMR, MS, HRMS, and XRD were adopted to analyze the chemical structure of Nilvadipine. Results The structure of nilvadipine was 3-methyl-5-（1-methylethyl）-4-（RS）-2-cyano-6-methyl-4-（3-nitrophenyl）-1,4-dihydropyridine-3, 5-dicarboxylate. Conclusion This result is accurate and can provide a comprehensive reference for production and identification of nilvadipine.