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N-取代-5-甲(乙)基吲哚酮的简便合成 被引量：1

Convenient synthesis of N-substituted-5-methyl(ethyl) indolin-2-ones
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摘要 以5-甲(乙)基靛红1a-b为原料,在其氮上发生烃基化反应,以76.4-97.4%的产率合成了一系列N-烃基-5-甲(乙)基靛红2a-j,然后2a-j在水合肼作用下直接发生还原反应,以75.2-92.2%的产率得到了N-烃基-5-甲(乙)基吲哚酮3a-j。通过对两步反应的改进,达到了高产率、低成本和简便的目的。其中2f-j,3c和3e-j是未见文献报道的新化合物,其结构经红外光谱、质谱和核磁共振谱得以证实。 A series of N-alkyl-5-methyl/ethylindoline-2,3-diones 2a-j were synthesized in the yield of 76. 4-97. 4%through the al-kylation reaction of 5-methyl（ethyl）indoline-2,3-diones 1a-b. The resulting 2a-j were then underwent the reduction reaction with hydrazine hydrate directly to give N-alkyl-5-methyl（ ethyl） indolin-2-ones 3a-j in the yield of 75. 2-92. 2%. The present synthetic route had the advantages such as high yield,low cost,and convenience. Among all the synthesized compounds,2f-j,3c and 3e-j were new compounds and their structures were confirmed by IR,MS,and1 H and 13 C NMR.
作者 高文涛 赵宾宾 赵鹏波 李阳
机构地区 渤海大学超精细化学品研究所
出处 《化学研究与应用》 CAS CSCD 北大核心 2014年第5期715-721,共7页 Chemical Research and Application
基金 辽宁省自然科学基金项目(201202001)资助
关键词 5-甲(乙)基靛红 烃基化 还原反应 水合肼 N-烃基-5-甲(乙)基吲哚酮 5-methyl/ethylindoline-2,3-diones alkylation reduction reaction hydrazine hydrate N-alkyl-5-methyl/ethylindolin-2-ones
分类号 O625 [理学—有机化学]
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参考文献29

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共引文献11

同被引文献17

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化学研究与应用
2014年 第5期

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