859例妊娠妇女凝血四项检测的临床意义

The Clinical Significance of Coagulation Testing in 859 Pregnant Women

目的:探讨妊娠妇女凝血四项检测的临床意义。方法:应用法国STAGO全自动血凝分析仪测定859例妊娠妇女及200例正常非妊娠女性的PT、APTT、TT、FIB值,分成早、中、晚及临产妊娠四期和妊娠期高血压疾病、正常妊娠组进行比较分析。结果:随着妊娠时间延长,早期、中期至晚期妊娠的PT值呈缩短趋势,不同时间比较差异均有统计学意义(P<0.05)。晚期与临产期PT值比较差异无统计学意义(P>0.05);随着妊娠时间的延长,APTT值呈缩短趋势,早期组与中期组比较差异有统计学意义(P<0.05),其他妊娠期APTT值比较差异均无统计学意义(P>0.05)。妊娠四个时期的TT值比较差异均无统计学意义(P>0.05)。早期、中期至晚期妊娠的FIB值比较差异均无统计学意义(P>0.05)。临产期FIB值明显升高,与其他各组比较差异均有统计学意义(P<0.05)。妊娠期高血压疾病组和正常妊娠组的PT、APTT、TT值比非妊娠组明显降低,FIB值明显升高,比较差异均有统计学意义(P<0.05)。妊娠期高血压疾病组的PT、APTT、TT值比正常妊娠组明显降低,FIB值明显升高,两组比较差异均有统计学意义(P<0.05)。结论:密切监测妊娠妇女的凝血四项变化,对预防血栓栓塞疾病和孕妇分娩过程中及产后大出血导致急性DIC的发生具有重要意义。

Objective： To investigate the clinical significance of coagulation testing in pregnant women. Method： PT, APTT, TT, FIB of 859 pregnant women and 200 normal non-pregnant women were analyzed by STAGO automated coagulation. 859 cases were divided into early, middle, late pregnancy and labor during pregnancy. 859 cases also were divided into pregnancy-induced hypertension and normal pregnancy group. Result： As a result of pregnancy time, PT value of early, mid-to late pregnancy was significantly shorter, and the difference were all statistically significant （P〈0.05 ） . APTT values of the early and mid-pregnancy was significantly shorter, and the difference were all statistically significant （ P〈0.05 ）. TT values was no significant difference, and the difference were statistically significant （ P〈0.05 ） . FIB values of labor during pregnancy was significantly increased, and the difference were statistically significant （P〈0.05） . PT, APTT, TT values of pregnancy-induced hypertension and normal pregnancy group was significantly lower than non-preguant group while FIB values was significantly increased, and the difference were all statistically significant （P〈0.05） . PT, APTT, TT values of pregnancy-induced hypertension group was significantly lower than the normal pregnancy group, and the difference were all statistically significant （P〈0.05） . while FIB was significantly increased （P〈0.05） . Conclusion： Coagulation changes are close monitored in pregnant women for the prevention of thromboembolie disease and acute DIC occurs of pregnant women during childbirth and postpartum hemorrhage.