血清CA125及HE4检测在卵巢肿瘤鉴别诊断中的临床意义

Clinical significance of detecting serum CAl25 and HE4 levels in differential diagnosis of ovariantumor

目的探讨附睾分泌蛋白4(HE4)、CA125单项及联合检测在卵巢肿瘤鉴别诊断中的临床意义。方法分别用ELISA法和化学发光免疫分析检测55例卵巢良性肿瘤患者、40例卵巢子宫内膜异位囊肿患者及30例卵巢癌患者血清HE4及CA125水平。结果卵巢癌组的CA125及HE4血清含量及阳性率明显高于其余两组(P<0.05);血清CA125单项检测对于卵巢癌的鉴别诊断具有较高的敏感性,HE4单项检测具有较高的特异性,但两者联合检测对于卵巢癌的鉴别诊断具有更高的敏感性、特异性及准确性。结论 CA125及HE4联合检测能够提高卵巢癌鉴别诊断的敏感性、特异性及准确性。

[ Objective ] To explore the value of HE8, CA125 alone or combined assay in differential diagnosis of ovarian tumor. [ Methods ] The serum HE4 and CA125 were measured by enzyme-linked immunosorbent assay（ELISA） and electro -- chemiluminescence immunoassay（ECLIA） respectively in the serum samples of benign ovarian tumour group（ 55 cases）, ovarian endometriotic cyst group（ 40 cases） and malignant ovarian tumour group （ 30 cases）. [ Results ] The serum levels and the positive rates of HE4 and CA125 for the patients with ovarian cancer were significantly higher than those in other two group（P〈 0.05）.The high sensitivity was found in single CA125 detection for the differential diagnosis of ovarian carcinoma. The high specificity was found in single HE4 detection for the differential diagnosis of ovarian carcinoma. But the higher sensitivity, specificity and accuracy were found in combined detection of CA125 and HE4 for the differential diagnosis of ovarian carcinoma. [ Conclusion ] The combined detection of CA125 and HE4 can improve the sensitivity, specificity and accuracy for the differential diagnosis of ovarian carcinoma .