摘要
结核病是单一致病菌感染引起死亡人数最多的疾病,严重危害人类的身体健康。微小RNA(miRNA)是一类含有21~25个核苷酸的小分子非编码RNA,通过抑制转录后基因表达或促进靶基因mRNA降解,在细胞的增殖、分化、衰老和凋亡中发挥重要作用。最近,大量研究发现miRNA参与调节结核感染后细胞的凋亡、促炎症因子的表达、炎症相关信号通路等活动,有可能成为结核诊断的新型检测指标。(中华检验医学杂岙,2014,37:330-333)
Tuberculosis a disease with the highest death rate by single pathogenic infection can cause serious harm to human health. MicroRNA (miRNA) is a classical single-stranded, short RNA molecules (about 21 to 25 nucleotides) that plays an important role in cell proliferation, differentiation, senescence and apoptosis by inhibiting the post-transcriptional gene expression or promoting degradation of target gene mRNA. Recent studies have shown that miRNA involved in the regulation of apoptosis, expression of pro-inflammatory cytokines, inflammation-related signaling pathways in tuberculosis infection. Meanwhile, miRNA may be a new biomarker for tuberculosis diagnosis. (Chin J Lab Med, 2014,37: 330- 333)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2014年第5期330-333,共4页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金资助项目(81371760)
国家重大传染病防治专项(2013X10003006-003-002)
第三军医大学科技成果转化基金(2012XZHI1)
关键词
结核
微RNAS
生物学标记
Tuberculosis
MicroRNAs
Biological markers