首发未治精神分裂症患者IL-6、IL-10和IL-12水平及影响因素

Plasma levels of IL-6,IL-10 and IL-12 and influencing factors in first-episode and neuroleptic-free schizophrenia patients

目的研究首发未治精神分裂症患者白细胞介素-6(IL-6)、白细胞介素-10(IL-10)和白细胞介素-12(IL-12)水平及影响因素。方法将137例研究对象分为患者组(n=67)和正常对照组(n=70)。采用夹心酶联免疫吸附测定法(ELISA)检测两组的血浆IL-6、IL-10和IL-12水平,用阳性和阴性症状评定量表(PANSS)评定精神症状严重性。结果患者组血浆IL-6浓度高于正常对照组(P=0.028),IL-10浓度低于正常对照组(P=0.013),IL-12浓度与正常对照组比较无统计学差异(P=0.258);PANSS阴性分与IL-10浓度呈正相关(β=1.9,P=0.011),吸烟量与IL-12浓度呈正相关(β=0.1,P=0.049)。结论精神分裂症患者免疫功能紊乱,细胞因子网络受损。精神分裂症的不同亚型间及男女患者间可能存在不同形式的免疫异常。

Objective To investigate the plasma levels of interleukin-6 （IL-6）, interleukin-10 （IL-10） and interleukin-12（IL-12） in first-episode and neuroleptic-free schizophrenia patients and their influencing factors.Methods The 137 subjects were divided into the patient group （n=67） and control group （n=70）.The plasma levels of IL-6, IL-10 and IL-12 were assayed by enzyme-linked immunosorbant assay （ ELISA） .The symptoms were measured by positive and negative syndrome scale （PANSS）.Results Compared with the control group, the patient group had the increased IL-6 levels （P=0.028） and decreased IL-10 levels （P=0.013）.No statistical difference of IL-12 levels was found between the two groups （P=0.258）.There existed positive correlations between negative subscore and IL-10 levels （β=1.9, P=0.011）, and the amount of cigarettes and IL-12 levels （β=0.1, P=0.049）.Conclusion Schizophre-nia is characterized by alteration of immunity and cytokine network damage.There may exist multi-form alterations of immunity among different subtypes and sexes of schizophrenia patients.