凋亡抑制因子Survivin在口腔鳞癌中的表达及其意义

Expression and significance of Survivin in human oral squamous cell carcinoma

目的探讨Survivin蛋白在口腔鳞癌中的表达及其临床相关性。方法采用免疫组织化学方法检测46例口腔鳞癌标本中Survivin蛋白的表达情况。结果 46例临床标本中Survivin阳性表达28例(60.8%)。Survivin表达与口腔鳞癌转移、临床分期密切相关,并且与患者预后显著相关。结论 Survivin蛋白可能在口腔鳞癌的发生发展中起重要作用,有可能作为判断口腔鳞癌的因素。

Objective To investigate the expression of survivin in human oral squamous cell carcinoma and its clinical significance.Methods The survivin expression in 46 cases of human oral squamous cell carcinoma was detected with SP immunohistochemical assay.Results A total of 28 cases （60.8%） presented positive survivin expression, which was closely correlated with metastasis, clinical stages and prognosis.Conclusion Survivin may play an important role in the tumorigenesis and development of human oral squamous cell carcinoma, serving as a valuable factor for its prog-nosis.