一氧化碳与移植器官缺血/再灌注损伤

Carbon Monoxide and Ischemia/Reperfusion Injury of Organ Grafts

一氧化碳(CO)是一种无色无味的惰性气体分子,由于它具有极强的干扰体内氧运输的特性而一直被认为是一种有害的废弃物。事实上,CO是体内重要的信号分子,低浓度的CO除了在调节血管张力、细胞生长与应急等方面发挥关键性作用,还具有抗凋亡作用。目前的研究显示,外源性低浓度的CO在各种应激条件下可以弥补内源性CO的短缺,发挥调节血管张力、抗炎、抗凋亡和抑制细胞增殖等作用。低浓度的外源性CO可以通过改善微循环、抗炎效应、抑制树突状细胞的成熟与迁徙、抑制细胞凋亡等机制减轻器官移植物缺血/再灌注损伤。

Carbon monoxide （CO） is an invisible, chemically inert, colorless and odorless gas and istoxic at high concentrations due to its interference with oxygen delivery. However, CO is a gaseous signalingmolecule and plays a crucial role in regulating vasomotor, cell growth, stress and anti-apoptosis. The studyshows that low concentrations of exogenous CO can compensate for shortage of endogenous CO at variousstress conditions, and exerts protective effects by regulating vasomotor, anti-inflammation, anti-apoptosis andinhibiting cell proliferation. Low concentrations of exogenous CO can reduce organ graft ischemia/reperfusioninjury through improving microcireulation, anti-inflammatory effect, inhibiting dendritic cell maturation andmigration, inhibition of apoptosis and other mechanisms.