肥胖与癌症关系的临床研究最新进展

Advancement in Clinical Researches of Correlation between Cancer and Obesity

肥胖患病率已经达到流行病的程度,肥胖是多种癌症发生的重要危险因素,例如大肠癌、乳腺癌、子宫内膜癌、前列腺癌、甲状腺癌等。体质量指数作为最常用的肥胖替代指标,可较好地反映肥胖癌症患者的临床特征、治疗疗效及预后。历年研究显示,对于肥胖与癌症关系的各临床研究得到的结论并不完全趋于一致。肥胖作为大多数常见癌症的一个重要危险因素,其作用机制的研究结果尚不明晰,从肥胖到癌症的发生、发展过程中干扰因素非常多,临床研究应根据需要适当选用,通过更有力的证据找出两者的关系,以期减少癌症的发生、发展,提高癌症患者预后的生活质量。

The incidence of obesity has reached the epidemic disease level, and obesity has been identi-fied as an important risk factor for several cancers,including colorectal prostate cancer, breast cancer, endorn-etrial cancer, prostate cancer and thyroid cancer. BMI, the most common alternative index for obesity, may bea better reflection of clinical characteristics, efficacy and prognosis of patients with cancer. Review of the pastresearch literature indicate that the clinical researches about cancer and obesity are not completely consist-ent. Biological mechanisms underlying the relationship between obesity and cancer are not well understood.There are many interference factors in the relationship between obesity and cancer,some of these factors maybe considered or excluded in the clinical research, so as to find the exact relationship between obesity andcancer, with the expectation to reduce the occurrence and development of cancer, and improve the quality ofsurvival for the patients.