KIR2DL3/HLA-C1基因组合与HCV感染相关性研究进展

Research Progress of the Correlation between KIR2DL3 /HLA-C1 Combination and HCV Infection

丙型肝炎病毒(HCV)感染是一个全球性的健康难题,丙型肝炎引起的肝硬化相关性死亡已经成为肝病中重要的病因之一。研究表明,人类白细胞抗原(HLA)以及其特异配体杀伤细胞免疫球蛋白样受体(KIR)与HCV感染具有相关性,其中KIR2DL3和HLA-C1与HCV感染的相关性已经得到证实。KIR2DL3和HLA-C1结合的亲和力低,减少了自然杀伤细胞的抑制作用,间接影响机体对HCV感染的免疫能力。该文将从KIR2DL3和HLA-C1在人群中的发生率、HCV感染过程中抗病毒免疫以及对肝移植后HCV再感染的影响等几个方面进行综述。

Hepatitis C virus（HCV） infection is a global health problem. Cirrhosis-correlated death resulted from HCV has become an important cause of liver diseases. Researches show that the human leukocyte antigen（HLA） and its specific ligand named killer cell immunoglobnlin-like receptor（KIR） are associated with HCV infection. It has been confirmed that KIR2DL3/HLA-C1 is correlated with HCV infection. The low binding affinity of KIR2DL3 and HLA-C1 weakens the inhibition of NK cell,and indirectly affects immunity against HCV infection. Here is to make a review of KIR2DL3 and HLA-C1 frequencies among population, antiviral immunologic function in process of HCV infection and its impact on HCV reinfection after liver transplantation.