转化生长因子β在器官移植排斥反应中的研究进展

Research Progress of TGF-β in Organ Transplant Rejection

转化生长因子β(TGF-β)家族是一个有着多效性的细胞因子,具有调节细胞的增殖、分化、迁移、生存等功能。近年来具有免疫抑制功能的TGF-β被广泛承认和研究,在抑制心脏、肾脏、肝脏等器官移植排斥反应方面有较多报道。该文对TGF-β在心脏、肾脏、肝脏等器官移植中的免疫抑制机制进行综述,认为TGF-β是一种诱导和调节移植耐受的细胞因子并介导抗炎作用在免疫反应中起到重要作用。

Transforming growth factor beta （TGF-β） family is a pleiotropie cytokine, regulating cell proliferation,differentiation, survival, migration, and other functions. With immune suppression function ofI TGF-β in recent years being widely recognized and, has been repotted more in the inhibition of the heart, I kidneys, liver and other organ transplant rejection reactions. Here is to make a review of the immunosuppres- β sire mechanism of TGF-β in the heart, kidneys, liver and other organ transplants, and it＇s considered that TGF-β is an induction and regulation of transplantation tolerant eytokine which plays an important role in the immune resonse through mediating anti-inflammatory effects.