摘要
肝切除术后,由细胞因子、生长因子及代谢性因子诱发的众多互联信号转导通路反应参与了肝再生的发生、发展及终止。近来研究发现,胆汁酸作为信号分子,通过激活相关受体在肝再生过程中发挥重要作用,其是目前肝再生研究的热点。胆汁酸通过激活肠道法尼酯X受体诱导产生的成纤维细胞生长因子15参与调节胆汁酸代谢,促进了肝再生。
A multitude of interconnected signaling pathways provocation by cytokines, growth factors and metabolic factors are involved in the initiation, progression and termination of the liver regeneration after hepateetomy. Recent evidence suggests that bile acid plays an important role in liver regeneration by activating the associated receptors as signaling molecules, it is the hot spot in liver regeneration field. Bile acid induces farnesoid X receptor,and FXR induces fibroblast growth factor 15 ,which participates in the regulation of bile acid metabolism and liver regeneration.
出处
《医学综述》
2014年第9期1567-1570,共4页
Medical Recapitulate
