45例早发型子痫前期患者血清chemerin、CRP的变化及其意义

The express and research of chemerin and CRP in 45 patients with early-onset preeclampsia

目的探讨血清chemerin及C反应蛋白(CRP)在不同体质量指数(BMI)早发型子痫前期患者血清中的表达及意义。方法选取该院早发型子痫前期(PE)患者45例作为研究组,其中轻度PE(MPE)组28例,重度PE(SPE)组17例;30例妊娠结局正常孕妇作为对照组。检测不同BMI PE患者及健康孕妇血清chemerin、CRP蛋白及血脂水平。结果 MPE组与SPE组的chemerin蛋白表达水平分别为(379.18±52.09)ng/L、(481.27±63.12)ng/L,明显高于对照组(316.08±51.90)ng/L,差异有统计学意义(P<0.05);而CRP的水平分别为(7.59±1.41)mg/L、(11.74±1.61)mg/L明显高于对照组(3.47±1.27)mg/L,差异有统计学意义(P<0.05);研究组超质量/肥胖血清chemerin及CRP的水平分别为(424.64±46.61)ng/L、(8.32±3.82)mg/L,高于正常体质量组(331.66±51.77)ng/L、(5.93±2.95)mg/L,差异有统计学意义(P<0.05),不同孕期BMI增长患者chemerin、CRP蛋白表达也存在差异。相关分析显示,血清chemerin与BMI、收缩压、舒张压、三酰甘油呈正相关,CRP与BMI呈正相关。结论血清chemerin及CRP升高可能导致PE的发生、发展并与BMI密切相关。

Objective The purpose of this study was to compare chemerin and CRP levels between women with and without ear‐ly‐onset preeclampsia based on maternal body mass index （BMI） .Methods 45 patients with early onset preeclampsia （gestation week is less than 34 weeks） ,30 normal pregnancy women were enrolled in the study .The serums levels of chemerin and CRP were measured in these pregnancy women .Results The chemerin [（379 .18 ± 52 .09）ng/L ,（481 .27 ± 63 .12）ng/L] and CRP [（7 .59 ± 1 .41）mg/L ,（11 .74 ± 1 .61）mg/L] levels in MPE and SPE were significantly higher than those [（316 .08 ± 51 .90）ng/L ,（3 .47 ± 1 .27）mg/L]in normal pregnancy women（P〈0 .05） .While the chemerin（424 .64 ± 46 .61）ng/L and CRP （8 .32 ± 3 .82）mg/L levels increased with maternal BMI in patients overweight and obese women levels compared with normal weight women [（331 .66 ± 51 .77）ng/L ,（5 .93 ± 2 .95）mg/L] ,the difference are significant（P〈0 .05） .The correlation analysis showed that the chemerin were positively correlated with BMI ,systolic blood pressure ,diastolic blood pressure ,triglycerides ,and CRP were positively correlated with BMI .Conclusion The expression of chemerin and CRP were associated with severity of preeclampsia and BMI .