4,5-二碘邻苯二甲腈的合成

A Research on the Synthesis of 4,5-Diiodophthalonitrile

合成了一种新的酞菁化合物的前驱体,以邻苯二甲酰亚胺为起始原料,经30%的发烟硫酸碘化得到4,5-二碘邻苯二甲酰亚胺,氨解、脱水得到4,5-二碘邻苯二甲腈。考察了碘化的影响因素,柱层析分离得到高纯度的4,5-二碘邻苯二甲腈,反应总收率为56%,目标产物结构经1 H NMR,13C NMR确认。

In order to synthesize a new precursor of phthalocyanine compound, 4,5-Diiodophthalirnide was prepared by iodization of phthalimide by 30% fuming sulfuric acid, after ammonolysis, dehydration 4,5- diiodophthalonitrile was achieved. Throughing column chromatography, high-purity of 4,5-diiodophtha- lonitrile was achieved. Investigating the effect of iodization, the total yield was 56%. The structures of the intermediates and target product were identified by 1H NMR,13C NMR.