不同剂量舒芬太尼对瑞芬太尼复合全麻患者恢复期质量的影响

Influences of different doses of sufentanil on recovery quality for patients under general anesthesia with remifentanil

目的:探讨研究不同剂量舒芬太尼对瑞芬太尼复合全麻患者恢复期质量的影响。方法:选取行腹部手术的患者136例,随机分为A、B、C、D四组,每组34例。A组为对照组,给予患者等剂量的生理盐水,B、C、D组患者给予舒芬太尼剂量分别为0.10μg/kg,0.15μg/kg,0.20μg/kg,比较分析四组患者的自主呼吸时间、苏醒时间和拔管时间,观察四组患者的三种评分,包括VAS评分(疼痛指标评分)、BCS评分(舒适评分)以及Ramsay评分(镇静评分)。结果:四组患者的自主呼吸时间、苏醒时间和拔管时间未见显著性差异(P>0.05);而四组患者中A组与其他B、C、D三组的VAS评分、BCS评分以及Ramsay评分情况具有明显差异,以C组的评分结果为最佳,P<0.05,具有统计学意义。结论:使用舒芬太尼的最佳剂量为0.15μg/kg,对瑞芬太尼复合全麻患者恢复期质量有较高的疗效,具有较佳的镇痛作用,不仅可以改善患者的疼痛感,还可以增强患者的舒适度,在临床上值得推广使用。

Objective：To investigate influences of different doses of sufentanil on recovery quality for patients under general anesthesia with remifentanil. Methods：136 cases with abdominal surgery in our hospital were randomly divided into A（control group）, B,C,D four groups,34 cases in each group. A group was administered equivalent doses of saline,whereas the B,C and D groups were given 0. 10μg,0. 15μg,and 0. 20μg sufentanil. The spontaneous breathing time,recovery time and extubation time of the four groups were compared and analyzed. Further,VAS score（pain index score）,BCS score（comfort score） and Ramsay score（sedation score） of the four groups were observed. Results： There were no significant differences among the four groups in the breathing time,recovery time and extubation time（P〉 0. 05）. There were significant differences among A group and B,C,and D groups in VAS score, BCS score and Ramsay score,the scores of C group was the best,and it had statistical significance（P〈 0. 05）. Conclusions： The optimal dose of sufentanil of 0. 15μg has a higher efficacy on remifentanil anesthesia patients,and it has a better analgesic effect; further, it could not only can improve the patient＇s pain,but also can enhance patients＇ comfort,and is worthy of promoting in clinical use.