GSTT1基因多态性与亚洲人群前列腺癌易感性的Meta分析

Polymorphism of GSTT1and prostate cancer in Asian people:a Meta-analysis

目的探讨亚洲人群谷胱甘肽巯基转移酶基因GSTT1多态性与前列腺癌易感性的关系。方法检索PubMed、EMBase、CBM、CNKI、VIP、万方数据平台从建库到2014年2月1日的文献,对所纳入的研究,运用RevMan 5.2软件进行Meta分析。结果共纳入11篇病例对照研究,累计样本量为3 290例,其中前列腺癌病例组1 172例,对照组2 118例。Meta分析结果可见将亚洲作为整体人群,GSTT1无效基因型与前列腺癌易感性未呈现出显著性相关（OR=1.03,95%CI=0.77～1.39,P=0.83）。亚组分析提示,伊朗人群中GSTT1无效基因型与前列腺癌易感性呈现出显著性负相关（OR=0.61,95%CI=0.38～0.98,P=0.04）;但在印度人群中,GSTT1无效基因型与野生型相比,则显示出能显著增加前列腺癌易感性（OR=1.56,95%CI=1.05～2.31,P=0.03）。漏斗图显示各文献间无明显发表偏倚。结论在部分亚洲人群中GSTT1无效基因型与前列腺癌易感性可能存在显著的相关性。

Objective To explore the association between GSTT1 polymorphism and prostate cancer in Asian people. Methods Databases,including PubMed,EMBase,CBM,CNKI,VIP, Wanfang Data,were searched to get related studies.Data analysis was conducted by Revman 5 .2 software. Results Eleven case-control studies were included.Totally,using M-H method in the random-effects model,the GSTT1 null genotype was not associated with prostate cancer in Asian people （OR=1.03,95%CI=0.77-1.39,P=0.83）.In subgroup analysis,the GSTT1 null genotype was associated with prostate cancer in Indian and East Asian people （OR=0 .6 1 ,9 5% CI=0 .3 8-0 .9 8 , P=0.04）（OR=1.56,95%CI=1.05-2.31,P=0.03）.Funnel plot revealed there was not existence of publication bias. Conclusions This Meta-analysis suggests that there may be a relationship be-tween the GSTT1 null genotype and prostate cancer in some Asian people.