2-丁炔-1,4-二苯合成工艺研究

Research of Synthetic Process of 2-Butyne-1,4-dibenzene

以2-丁炔-1,4-二(对甲苯磺酸酯)为起始原料,在AlCl3催化下和苯发生傅-克烷基化反应,合成2-丁炔-1,4-二苯。考察了AlCl3和磺酸酯的物质的量比、溶剂种类和用量、反应时间、反应温度对产物收率的影响,确定适宜的反应条件如下:n(AlCl3)∶n(磺酸酯)∶n(苯)为2.6∶1∶2.8、反应时间为2h、反应温度为40℃,在此条件下,2-丁炔-1,4-二苯收率为60.1%。产物经元素分析、IR和1HNMR确证。

2-Butyne-1,4-dibenzene was prepared by the reaction of 2-butyne-1,4-bis（p-toluenesulphonate） and benzene with aluminum chloride as catalyst.The effects of reaction conditions on the yield of product,such as molar ratio of aluminum chloride to sulphonate,type and volume of solvent,reaction time and reaction temperature were investigated.The optimal reaction conditions were obtained as follows：the molar ratio of aluminum chloride to sulphonate to benzene was 2.6∶1∶2.8,reaction time was 2hand reaction temperature was 40 ℃.Under above conditions,the yield of 2-butyne-1,4-dibenzene was 60.1%.The structure of product was confirmed by elemental analysis,IR and 1 HNMR.