摘要
在多壁碳纳米管(MWCNTs)表面引入酸性基团进行酸化改性,用均相合成法合成壳聚糖-叶酸(CHI-FA)偶联物,并制备出壳聚糖-叶酸修饰的多壁碳纳米管(MWCNTs-CHI-FA)复合纳米材料。利用Zeta电位、红外光谱、紫外吸收光谱和透射电镜对其进行了表征。以抗肿瘤药物阿霉素(DOX)为模型药物、MWCNTs-CHI-FA为药物载体,对该递药体系的靶向给药性能进行了研究。体外细胞实验证实:所合成的多壁碳纳米管递药体系具有良好的药物靶向输送效果,对叶酸受体表达较高的HeLa肿瘤细胞具有明显的体外细胞抑制活性。
Multi-walled carbon nanotubes(MWCNTs)acidified by mixed acid and functionalized by folate(FA)conjugated chitosan(CHI)as drug carrier were characterized by Zeta potential,IR,UV and TEM.Doxorubicin(DOX),as a model of anticancer drug,was encapsulated into(or onto)the functionalized carbon nanotubes.The resulting DOX-MWCNTs-CHI-FA had good targeting drug delivery ability and exhibited good inhibition activity against the folate receptor[FR(+)]HeLa tumor cells in vitro.
出处
《化学与生物工程》
CAS
2014年第5期40-43,56,共5页
Chemistry & Bioengineering
关键词
多壁碳纳米管
叶酸
壳聚糖
靶向递药
阿霉素
multi-walled carbon nanotubes(MWCNTs)
folate(FA)
chitosan
targeting drug delivery
doxorubicin(DOX)