缝隙连接与癫癎

Gap junctions and epilepsy

缝隙连接是细胞膜上的一种特殊结构,是相邻细胞间唯一能直接进行能量、物质和信息交换的特殊通道.其在神经元电活动的维持、神经元快速同步化、神经元的发育中发挥着十分重要的作用.癫癎是一种复杂的临床综合征,其发病机制复杂,至今仍尚未明确.有研究证实缝隙连接在癫癎的发生、发展中具有重要的作用.该文就缝隙连接的基本结构、分布与功能,以及缝隙连接与癫癎关系的研究作一综述.

Gap junction, a special structure in cell membrane,constitutes the only direct communication channel of energy, material and information exchange between adjacent cells. Gap junction plays an important role in the maintenance of electrical activity of neurons, the rapid synchronization of neurons and neuronal devel- opment. Epilepsy, caused by a variety of causes,is a complex clinical syndrome. The pathogenesis of epilepsy is complex. And it＇s still not fully understood. Studies in recent years have found that gap junction plays a very im- portant role in the pathogenesis and development of epilepsy. The structure, distribution and functions of gap junction and the relationship between gap junction and epilepsy are reviewed in the paper.