免疫抑制剂在儿童难治性肾病综合征的应用进展被引量：10

Application progress of immunosuppresive agent in refractory nephritic syndrome in children

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摘要难治性肾病综合征是导致儿童终末期肾病的主要原因之一,也是临床治疗的棘手问题.近年来,新型免疫抑制剂,极大地改善了难治性肾病综合征患儿的预后.该文就近年来常用的免疫抑制剂环磷酰胺、环孢素、他克莫司、吗替麦考酚酯、来氟米特、利妥昔单抗等在不同类型的儿童难治性肾病综合征中的应用进展作一综述. Refractory nephrotic syndrome （RNS） is one of the main causes of end-stage renal disease to children and also a difficult issue in clinic treatment. In recent years, the emergence of new irnmunosuppresive a- gents greatly improved the prognosis of children with RNS. In this paper, the application progress of immunosup- presive agents such as cyclophosphamide, ciclosporin, tacrolimus, mycophenolate mofetil, leflunomide and ritux- imab which were commonly used in recent years to different types of children with RNS are summarized.

作者杨乔焕高岩

机构地区广州市妇女儿童医疗中心肾内科佛山市禅城区中心医院普儿科

出处《国际儿科学杂志》 2014年第3期281-287,共7页 International Journal of Pediatrics

关键词免疫抑制剂儿童难治性肾病综合征 Immunosuppressive agents Children Refractory nephritic syndrome

分类号 R726.9 [医药卫生—儿科]

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1Cammas B, Harambat J, Bertholet-Thomas A, et al. Long-term effects of cyclophosphamide therapy in steroid-dependent or frequently re- lapsing idiopathic nephrotic syndrome [ J ]. Nephrol Dial Transplant, 2011,26( 1 ) :178-184.
2Zagury A, de Oliveira AL, de Moraes CA, et al. Long-term follow-up after cyclophosphamide therapy in steroid-dependent nephrotic syn- drome [ J]. Pediatr Nephrol,2011,26 (6) :915-920.
3Kyrieleis HA, Levtchenko EN, Wetzels JF. Long-term outcome after cyclophosphamide treatment in children with steroid-dependent and frequently relapsing minimal change nephrotic syndrome [ J ]. Am J Kidney Dis,2007,49(5) :592-597.
4Latta K, von Schnakenburg C, Ehrich JH. A meta-analysis of cytotox- ic treatment for frequently relapsing nephrotie syndrome in children [ J]. Pediatr Nephrol,2001,16( 3 ) :271-282.
5Al Salloum AA. Pulse cyclophosphamide therapy for steroid-resistant focal segmental glomerulosclerosis in children [ J]. Ann Saudi Med, 2004,24( 1 ) :27-30.
6Buyukcelik M, Cengiz N, Dursun H, et al. Intravenous pulse cyclo- phosphamide therapy in focal segmental glomerulosclerosis[ J ]. Clin Nephrol,2006,65 ( 1 ) :7-12.
7Plank C, Kalb V, Hinkes B, et al. Cyclosporin A is superior to cyclo- phosphamide in children with steroid-resistant nephrotic syndrome-a randomized controlled mulficentre trial by the Arbeitsgemeinschaft fur Padiatrische Nephrologie [ J ]. Pediatr Nephrol, 2008,23 ( 9 ) : 1483- 1493.
8Ishikura K, Ikeda M, Hattori S, et al. Effective and safe treatment with cyclosporine in nephrotic children: a prospective, randomized multi- center trial[ J]. Kidney Int,2008,73 (10) : 1167-1173.
9夏正坤,刘光陵,高远赋,伏洁,傅元凤,张连丰,樊忠民.环孢素A治疗儿童不同病理类型肾病综合征83例的疗效观察[J].中华儿科杂志,2003,41(11):813-816. 被引量：6
10Hodson EM, Willis NS, Craig JC. Non-corticosteroid treatment for nephrotic syndrome in children [ J ]. Cochrane Database Syst Rev, 2008,23 ( 1 ) : CD002290.

二级参考文献85

1Meyrier A, Simon P, Perret G, et al. Remission of idiopathic nephrotic syndrome after treatment with cyclosporin A. Br Med J, 1986,292:789-792.
2Hodson EM, Willis NS, Craig JC. Non-corticosteroid treatment for nephrotic syndrome in children(Review). Cochrane Database Syst Rev,2008,23 : CD002290.
3Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials : is blinding necessary? Control Clin TriMs, 1996,17 : 1-12.
4Tejani A, Gonzalez R, Rajpoot D, et al. A Randomized trial of cyclosporine with low-dose prednisone compared with high-dose prednisone in nephrotic syndrome. Transplant Proc, 1988,20:262- 264.
5Tejani A, Suthanthiran M, Pomrantz A. A randomized controlled trial of low-dose prednisone and cyclosporine versus high-dose prednisone in nephrotic syndrome of children. Nephron, 1991,59: 96-99.
6Niaudet P. Comparison of cyclosporin and chlorambucil in the treatment of steroid-dependent idiopathic nephrotic syndrome: a multicentre randomized controlled trial. Pediatr Nephrol, 1992,6 : 1-3.
7Ponticelli C, Rizzoni G, Edefonti A, et al. A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome. Kidney Int, 1993,43 : 1377-1384.
8Ponticelli C, Edefonti A, Ghio L, et al. Cyclosporin versus cyclophosphamide for patients with steroid-dependent and frequently relapsing idiopathic nephrotie syndrome:a muhieentre randomized controlled trial. Nephrol Dial Transplant, 1993, 8 : 1326-1332.
9Lieberman KV, Tejani A. A randomized double-blind placebo- controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children. J Am Soc Nephrol, 1996,7:56-63.
10Dorresteijn EM, Kist-van Holthe JE, Levtchenko EN, et al. Mycophenolate mofetil versus cyclosporine for remission maintenance in nephrotic syndrome. Pediatr Nephrol, 2008,23 : 2013-2020.