摘要
核因子kappaB(NF-κB)抑制蛋白(IκB)是NF-κB信号通路中的重要成员,主要调节NF-κB的激活及转录。目前研究认为,IκBα是IκB家族中的重要成员之一,IκBα在所有真核生物的固有免疫和适应性免疫中均发挥作用,介导了多种感染性疾病、免疫性疾病、肿瘤、基因病等的发生。本文对IκBα的结构、在信号通路中的作用、生物学功能、与免疫及感染相关疾病的关系进行综述。
Inhibitor of nuclear factor kappa-B（IκB）, an important member of nuclear factor kappa B（NF-κB） signaling pathway, is an essential adaptor in the regulation of NF-κB transcriptional activity. It is currently accepted that IκB plays an essential role in innate immunity and adaptive immunity, infectious diseases, autoimmune diseases, cancers and genetic diseases. Here we will review the structure, fundamental function of IκB and its role in signal transduction. Furthermore, we will also illustrate the relationship between IκB and the autoimmune diseases or infectious diseases.
出处
《中华临床医师杂志（电子版）》
CAS
2014年第3期138-141,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
四川省科技厅科研基金资助项目(05JY029-054-2
07SG004-005)
关键词
NF-ΚB
信号传导
免疫系统疾病
感染性疾病
NF-kappa B
Signal transduction
Immune system diseases
Infectious diseases
